Fryer et al. Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua. Science. 2011 Nov 4;334(6056):690-3.
Spinocerebellar ataxia type 1 (SCA1) is caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). To determine the long-term effects of exercise, this study implemented a mild exercise regimen in a mouse model of SCA1 and found a considerable improvement in survival accompanied by up-regulation of epidermal growth factor and consequential down-regulation of Capicua, which is an ATXN1 interactor.
See commentary: Gitler. Neuroscience. Another reason to exercise. Science. 2011 Nov 4;334(6056):606-7.
"The scientific case for regular aerobic exercise is compelling. Would you not agree?"